Preparation and characterization of 45S5 bioactive glass/based scaffolds reinforced with genipin cross-linked gelatin loaded with PHBV microspheres with vancomycin release function

 

Investigator: Inês Barroso (Gaststudentin, Universität A Coruña, Spanien)Inês Barroso

 

Betreuer: Katharina Schuhladen, Dr. Maizlinda Izwana Idris, Prof. Aldo R. Boccaccini
 

The aim of this study is the development and characterization of bioactive glass based scaffolds with enhanced mechanical properties and drug delivery function. The scaffolds will be prepared by the foam replication method and reinforced with cross-linked gelatin by a dip coating technique in order to improve the mechanical properties [1]. Moreover, the reinforced scaffolds will be further combined with drug microcarriers with controlled release function, in order to avoid possible postoperative infections. Vancomycin is an antibiotic with good efficacy in the treatment of infections caused by gram positive bacteria. Vancomycin loaded microcarriers will be produced by a water-in-oil-in-water double emulsion solvent evaporation method previously established in our Institute [2].

[1] W. Li, H. Wang, Y. Ding, E.C. Scheithauer, O.-M. Goudouri, A. Grünewald, et al., Anti-bacterial 45S5 bioglass®-based scaffolds reinforced with genipin cross-linked gelatin for bone tissue engineering, J. Mater. Chem. B 33673378 (2015).

[2] W. Li, Y. Ding, R. Rai, J. A. Roether, D. W. Schubert, A. R. Boccaccini, Preparation and characterization of PHBV microsphere/45S5 bioactive glass composite scaffolds with vancomycin releasing function, Materials Science and Engineering: C, Volume 41, 1 August 2014, Pages 320-328.